SYNTHESIS, CHARACTERIZATION OF COPPER(II) COMPLEX WITH TETRADENTATE N2O2 AND POTENTIAL CONTRIBUTION AS PROMISING ANTIBACTERIAL STUDIES
DOI:
https://doi.org/10.46754/umtjur.v5i2.356Keywords:
N2O2 Schiff base, Cu(II) complex, Spectral studies, Antibacterial studies, Biological activityAbstract
A square planar Schiff base complex, Cu(H2L) namely N,N’-bis(4-methyl-α-salicylidene) propane-1,3-diaminecopper(II) through the condensation reaction of ligand with copper(II) acetate in the molar ratio of 1:1 in acetonitrile solvent was successfully synthesized. The obtained complex was characterized using elemental analysis of carbon, hydrogen, and nitrogen (CHN), Fourier Transform Infrared spectroscopy (FTIR) and electronic spectra of ultraviolet-visible (UV-vis) spectroscopy. FTIR confirmed the coordinates the metal ion to form mononuclear complex via tetradentate (ONNO) atoms of the phenolic group and azomethine group, respectively. The antibacterial studies of H2L and its Cu(H2L) were determined by screening the compounds against selected various Gram (+) and Gram (-) bacterial strains such as Staphylococcus epidermidis, Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Enterobacter cloacae, and Escherichia coli. Indeed, preliminary results exhibited Cu(H2L) more active than the free ligand and displayed promising antibacterial activity, while no effect has been observed on strains for H2L.
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